Estro-Cleanse PLUS works by targeting the core issues behind estrogen dominance and testosterone depletion — two of the most overlooked factors in men’s declining health and vitality. The formula begins its work in the liver, where Indole-3-Carbinol (I3C) initiates Phase I detoxification. This step helps convert aggressive, harmful estrogens into less potent forms, making them easier for the body to eliminate. I3C acts as a vanguard, weakening the estrogenic assault before it can do further damage.

Following I3C, DIM (Diindolylmethane), a powerful compound derived from cruciferous vegetables, steps in as the body’s aromatase blocker. Aromatase is the enzyme that converts testosterone into estrogen — essentially stealing your masculinity. DIM neutralizes this “double agent,” helping ensure that testosterone remains active and available to fuel strength, energy, and sexual performance. It also supports the further breakdown of estrogen, assisting the body in completing Phase II detox, which clears estrogen from the system through water-soluble excretion.

To protect the liver and further boost detoxification, Resveratrol acts as a powerful antioxidant shield. It calms inflammation, neutralizes free radicals generated during hormone processing, and protects vital tissues from oxidative stress. Tulsi (Holy Basil) complements this effect by regulating stress hormones like cortisol, supporting the liver, and adding its own aromatase-blocking properties — making it an essential multitasker in the formula.

Finally, Chasteberry (Vitex) takes a more indirect yet critical approach. It reduces prolactin levels — a hormone that, when elevated in men, can lower libido and promote estrogen dominance. At the same time, it supports healthy progesterone levels, which act as a natural buffer against estrogen’s effects and help maintain testosterone production and balance. This two-pronged hormonal recalibration is key to long-term masculine health.